During Epaphroditus Ransom's gubernatorial term (1848-1850), the
Kalamazoo Regional Psychiatric Hospital was established. Following his term as governor, Ransom became the first president of the Michigan Agricultural Society, which was instrumental in the creation of both the
Michigan State Fair and
Michigan State University. He was also a regent of the
University of Michigan (1850-1852), a founder of the village of Augusta and a state representative (1853-1854). In 1857 President James Buchanen appointed Ransom receiver of the Kansas Osage Land Office in Fort Scott, Kansas. He died in Kansas in 1859. His body was returned to Kalamazoo, where it was interred in Mountain Home Cemetery.